Runs of Homozygosity in Modern Chicken Revealed by Sequence Data
نویسندگان
چکیده
منابع مشابه
Inferring Demography from Runs of Homozygosity in Whole-Genome Sequence, with Correction for Sequence Errors
Whole-genome sequence is potentially the richest source of genetic data for inferring ancestral demography. However, full sequence also presents significant challenges to fully utilize such large data sets and to ensure that sequencing errors do not introduce bias into the inferred demography. Using whole-genome sequence data from two Holstein cattle, we demonstrate a new method to correct for ...
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Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of inferring individual autozygosity, all on the b...
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OBJECTIVES Recent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study runs of homozygosity (ROH) in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide. METHODS By sorting ROH into 3 length classes (short, intermediate, and long), we e...
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15 صفحه اولGenomic Runs of Homozygosity Record Population History and Consanguinity
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago....
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2020
ISSN: 2160-1836
DOI: 10.1534/g3.120.401860